7ME5

Structure of the extracellular WNT-binding module in Drl-2

Summary for 7ME5

Entry DOI	10.2210/pdb7me5/pdb
Related	7ME4
Descriptor	Tyrosine-protein kinase transmembrane receptor DRL-2, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	wnt signaling, receptor tyrosine kinases, acylation, growth factor signaling, co-receptor, pseudokinases, ligand, receptor, cancer, signaling protein
Biological source	Drosophila melanogaster (Fruit fly)
Total number of polymer chains	1
Total formula weight	18286.83
Authors	Shi, F.,Mendrola, J.M.,Perry, K.,Stayrook, S.E.,Lemmon, M.A. (deposition date: 2021-04-06, release date: 2021-10-13, Last modification date: 2023-10-18)
Primary citation	Shi, F.,Mendrola, J.M.,Sheetz, J.B.,Wu, N.,Sommer, A.,Speer, K.F.,Noordermeer, J.N.,Kan, Z.Y.,Perry, K.,Englander, S.W.,Stayrook, S.E.,Fradkin, L.G.,Lemmon, M.A. ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes. Cell Rep, 37:109834-109834, 2021 Cited by PubMed: 34686333 DOI: 10.1016/j.celrep.2021.109834 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation