7MBJ
Crystal structure of cGMP dependent protein kinase I alpha (PKG I alpha)CNB-A domain with R177Q mutation
Summary for 7MBJ
| Entry DOI | 10.2210/pdb7mbj/pdb |
| Descriptor | cGMP-dependent protein kinase 1 (2 entities in total) |
| Functional Keywords | cgmp dependent protein kinase i alpha, second messenger, thoracic aortic aneurysms and aortic dissections causing mutation, signaling protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 30551.66 |
| Authors | Kim, J.J.,Casteel, D.E.,Kim, C. (deposition date: 2021-03-31, release date: 2022-05-11, Last modification date: 2023-10-18) |
| Primary citation | Sharma, R.,Kim, J.J.,Qin, L.,Henning, P.,Akimoto, M.,VanSchouwen, B.,Kaur, G.,Sankaran, B.,MacKenzie, K.R.,Melacini, G.,Casteel, D.E.,Herberg, F.W.,Kim, C.W. An auto-inhibited state of protein kinase G and implications for selective activation. Elife, 11:-, 2022 Cited by PubMed: 35929723DOI: 10.7554/eLife.79530 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.26 Å) |
Structure validation
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