7M94

Bovine sigma-2 receptor bound to Roluperidone

Summary for 7M94

Entry DOI	10.2210/pdb7m94/pdb
Descriptor	Sigma intracellular receptor 2, Roluperidone, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
Functional Keywords	receptor, sterol, dimer, membrane protein
Biological source	Bos taurus (Bovine)
Total number of polymer chains	4
Total formula weight	89872.64
Authors	Alon, A.,Kruse, A.C. (deposition date: 2021-03-30, release date: 2021-12-15, Last modification date: 2023-10-18)
Primary citation	Alon, A.,Lyu, J.,Braz, J.M.,Tummino, T.A.,Craik, V.,O'Meara, M.J.,Webb, C.M.,Radchenko, D.S.,Moroz, Y.S.,Huang, X.P.,Liu, Y.,Roth, B.L.,Irwin, J.J.,Basbaum, A.I.,Shoichet, B.K.,Kruse, A.C. Structures of the sigma 2 receptor enable docking for bioactive ligand discovery. Nature, 600:759-764, 2021 Cited by PubMed: 34880501 DOI: 10.1038/s41586-021-04175-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.71 Å)

Structure validation