7M8M
CRYSTAL STRUCTURE OF THE SARS-COV-2(2019-NCOV) MAIN PROTEASE IN COMPLEX WITH COMPOUND 11
Summary for 7M8M
Entry DOI | 10.2210/pdb7m8m/pdb |
Descriptor | 3C-like proteinase, 5-[3-(3-chloro-5-propoxyphenyl)-2-oxo-2H-[1,3'-bipyridin]-5-yl]pyrimidine-2,4(1H,3H)-dione (3 entities in total) |
Functional Keywords | novel coronavirus, antiviral, drug design, viral protein, hydrolase |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) |
Total number of polymer chains | 2 |
Total formula weight | 68101.97 |
Authors | Deshmukh, M.G.,Zhang, C.H.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2021-03-30, release date: 2021-06-30, Last modification date: 2023-10-18) |
Primary citation | Deshmukh, M.G.,Ippolito, J.A.,Zhang, C.H.,Stone, E.A.,Reilly, R.A.,Miller, S.J.,Jorgensen, W.L.,Anderson, K.S. Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease. Structure, 29:823-, 2021 Cited by PubMed: 34161756DOI: 10.1016/j.str.2021.06.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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