7M8C

Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 230 s

Summary for 7M8C

• Entry DOI: 10.2210/pdb7m8c/pdb
• Descriptor: DNA polymerase eta, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), DNA/RNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*A)-D(P*A)-3'), ... (9 entities in total)
• Functional Keywords: dna polymerase, time resolved crystallography, deprotonation, dna binding protein, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 56049.32

Authors

Gregory, M.T.,Gao, Y.,Yang, W. (deposition date: 2021-03-29, release date: 2021-06-02, Last modification date: 2023-10-18)

• Primary citation: Gregory, M.T.,Gao, Y.,Cui, Q.,Yang, W.; Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34088846; DOI: 10.1073/pnas.2103990118

Experimental method

X-RAY DIFFRACTION (1.85 Å)