7M4T

Menin bound to M-1121

Summary for 7M4T

• Entry DOI: 10.2210/pdb7m4t/pdb
• Descriptor: Menin, methyl {(1S,2R)-2-[(1S)-2-(azetidin-1-yl)-1-(3-fluorophenyl)-1-{1-[(3-methoxy-1-{4-[(1S,4S)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptane-2-sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}ethyl]cyclopentyl}carbamate, praseodymium triacetate, ... (4 entities in total)
• Functional Keywords: inhibitor, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 63446.45

Authors

Stuckey, J. (deposition date: 2021-03-22, release date: 2021-08-11, Last modification date: 2023-10-18)

• Primary citation: Zhang, M.,Aguilar, A.,Xu, S.,Huang, L.,Chinnaswamy, K.,Sleger, T.,Wang, B.,Gross, S.,Nicolay, B.N.,Ronseaux, S.,Harvey, K.,Wang, Y.,McEachern, D.,Kirchhoff, P.D.,Liu, Z.,Stuckey, J.,Tron, A.E.,Liu, T.,Wang, S.; Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.; J.Med.Chem., 64:10333-10349, 2021; PubMed: 34196551; DOI: 10.1021/acs.jmedchem.1c00789

Experimental method

X-RAY DIFFRACTION (2.74 Å)