7M0T

Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Selumetinib

Replaces:  6V32

Summary for 7M0T

• Entry DOI: 10.2210/pdb7m0t/pdb
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, Serine/threonine-protein kinase B-raf, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, ... (5 entities in total)
• Functional Keywords: braf, mek1, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 77407.07

Authors

Li, K.,Gonzalez Del-Pino, G.,Ha, B.H.,Park, E.,Eck, M.J. (deposition date: 2021-03-11, release date: 2021-04-21, Last modification date: 2023-10-18)

• Primary citation: Gonzalez-Del Pino, G.L.,Li, K.,Park, E.,Schmoker, A.M.,Ha, B.H.,Eck, M.J.; Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34470822; DOI: 10.1073/pnas.2107207118

Experimental method

X-RAY DIFFRACTION (3.19 Å)