7LP0
Crystal structure of BPTF bromodomain in complex with inhibitor Pdy-3-077
Summary for 7LP0
| Entry DOI | 10.2210/pdb7lp0/pdb |
| Descriptor | Nucleosome-remodeling factor subunit BPTF, 4-chlorol-2-methyl-5-[[(3~{R})-1-methylpiperidin-3-yl]amino]pyridazin-3-one, DIMETHYL SULFOXIDE, ... (5 entities in total) |
| Functional Keywords | bptf, bromodomain, inhibitor, gene regulation, gene regulation-inhibitor complex, gene regulation/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 29626.56 |
| Authors | Chan, A.,Schonbrunn, E. (deposition date: 2021-02-11, release date: 2022-08-10, Last modification date: 2024-02-21) |
| Primary citation | Zahid, H.,Buchholz, C.R.,Singh, M.,Ciccone, M.F.,Chan, A.,Nithianantham, S.,Shi, K.,Aihara, H.,Fischer, M.,Schonbrunn, E.,Dos Santos, C.O.,Landry, J.W.,Pomerantz, W.C.K. New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64:13902-13917, 2021 Cited by PubMed: 34515477DOI: 10.1021/acs.jmedchem.1c01294 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
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