7LL9

D-Protein RFX-V2 Bound to the VEGFR1 Domain 3 Site on VEGF-A

Summary for 7LL9

• Entry DOI: 10.2210/pdb7ll9/pdb
• Descriptor: Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V2 (2 entities in total)
• Functional Keywords: d-protein, antagonist, biosynthetic protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 75168.91

Authors

Marinec, P.S.,Landgraf, K.E.,Uppalapati, M.,Chen, G.,Xie, D.,Jiang, Q.,Zhao, Y.,Petriello, A.,Deshayes, K.,Kent, S.B.H.,Ault-Riche, D.,Sidhu, S.S. (deposition date: 2021-02-03, release date: 2021-03-03, Last modification date: 2023-11-15)

• Primary citation: Marinec, P.S.,Landgraf, K.E.,Uppalapati, M.,Chen, G.,Xie, D.,Jiang, Q.,Zhao, Y.,Petriello, A.,Deshayes, K.,Kent, S.B.H.,Ault-Riche, D.,Sidhu, S.S.; A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.; Acs Chem.Biol., 16:548-556, 2021; PubMed: 33621466; DOI: 10.1021/acschembio.1c00017

Experimental method

X-RAY DIFFRACTION (2.9 Å)