7LK4
Crystal structure of BAK L100A in complex with activating antibody fragments
Summary for 7LK4
Entry DOI | 10.2210/pdb7lk4/pdb |
Descriptor | Bcl-2 homologous antagonist/killer, 7D10 antibody VL fragment, 7D10 antibody VH fragment, ... (5 entities in total) |
Functional Keywords | swap dimer, antibody fragments, apoptosis |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 178604.36 |
Authors | Robin, Y.A.,Colman, P.M. (deposition date: 2021-02-01, release date: 2022-02-09, Last modification date: 2023-10-18) |
Primary citation | Robin, A.Y.,Miller, M.S.,Iyer, S.,Shi, M.X.,Wardak, A.Z.,Lio, D.,Smith, N.A.,Smith, B.J.,Birkinshaw, R.W.,Czabotar, P.E.,Kluck, R.M.,Colman, P.M. Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the alpha 1-alpha 2 loop in BAK activation. Cell Death Differ., 29:1757-1768, 2022 Cited by PubMed: 35279694DOI: 10.1038/s41418-022-00961-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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