7LH8

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR JJ-II-131

Summary for 7LH8

Entry DOI	10.2210/pdb7lh8/pdb
Descriptor	Bromodomain-containing protein 4, (5R)-1-ethyl-5-(4-methylphenyl)-7-({1-[(4-nitrophenyl)methyl]piperidin-4-yl}methyl)-5,7,8,9-tetrahydro-1H-pyrrolo[3',4':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	small molecule inhibitor, drug discovery, epigenetics, transcription, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	16065.42
Authors	Schonbrunn, E.,Chan, A. (deposition date: 2021-01-21, release date: 2022-07-06, Last modification date: 2023-10-25)
Primary citation	Jiang, J.,Sigua, L.H.,Chan, A.,Kalra, P.,Pomerantz, W.C.K.,Schonbrunn, E.,Qi, J.,Georg, G.I. Dihydropyridine Lactam Analogs Targeting BET Bromodomains. Chemmedchem, 17:e202100407-e202100407, 2022 Cited by PubMed: 34932262 DOI: 10.1002/cmdc.202100407 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation