7LAF

15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor

Summary for 7LAF

• Entry DOI: 10.2210/pdb7laf/pdb
• Descriptor: Polyunsaturated fatty acid lipoxygenase ALOX15B, MANGANESE (II) ION, 3-{[(4-methylphenyl)methyl]sulfanyl}-1-phenyl-1H-1,2,4-triazole, ... (4 entities in total)
• Functional Keywords: lipoxygenase, inhibitor, allostery, complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, lipid binding protein, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 155422.47

Authors

Newcomer, M.E.,Gilbert, N.C.,Neau, D.B. (deposition date: 2021-01-06, release date: 2022-01-19, Last modification date: 2023-10-18)

• Primary citation: Tsai, W.C.,Gilbert, N.C.,Ohler, A.,Armstrong, M.,Perry, S.,Kalyanaraman, C.,Yasgar, A.,Rai, G.,Simeonov, A.,Jadhav, A.,Standley, M.,Lee, H.W.,Crews, P.,Iavarone, A.T.,Jacobson, M.P.,Neau, D.B.,Offenbacher, A.R.,Newcomer, M.,Holman, T.R.; Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.; Bioorg.Med.Chem., 46:116349-116349, 2021; PubMed: 34500187; DOI: 10.1016/j.bmc.2021.116349

Experimental method

X-RAY DIFFRACTION (2.44 Å)