7L6R

Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1), S-Adenosyl-L-homocysteine (SAH) and Manganese (Mn).

Summary for 7L6R

• Entry DOI: 10.2210/pdb7l6r/pdb
• Descriptor: 2'-O-methyltransferase, beta-D-fructopyranose, Non-structural protein 10, ... (11 entities in total)
• Functional Keywords: structural genomics, center for structural genomics of infectious diseases, csgid, nsp16, nsp10, complex, viral protein, sah, cap-1, viral protein-rna complex, viral protein/rna
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV,SARS-CoV-2); More
• Total number of polymer chains: 3
• Total formula weight: 52471.49

Authors

Minasov, G.,Shuvalova, L.,Rosas-Lemus, M.,Kiryukhina, O.,Brunzelle, J.S.,Satchell, K.J.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2020-12-23, release date: 2021-01-06, Last modification date: 2024-03-06)

• Primary citation: Minasov, G.,Rosas-Lemus, M.,Shuvalova, L.,Inniss, N.L.,Brunzelle, J.S.,Daczkowski, C.M.,Hoover, P.,Mesecar, A.D.,Satchell, K.J.F.; Mn 2+ coordinates Cap-0-RNA to align substrates for efficient 2'- O -methyl transfer by SARS-CoV-2 nsp16.; Sci.Signal., 14:-, 2021; PubMed: 34131072; DOI: 10.1126/scisignal.abh2071

Experimental method

X-RAY DIFFRACTION (1.98 Å)