7L26

HPK1 IN COMPLEX WITH COMPOUND 38

Summary for 7L26

Entry DOI	10.2210/pdb7l26/pdb
Descriptor	Mitogen-activated protein kinase kinase kinase kinase 1, 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1H-indazole-5-carbonitrile (3 entities in total)
Functional Keywords	hpk1 hematopoietic progenitor kinase, inhibitor complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	130584.49
Authors	Lesburg, C.A. (deposition date: 2020-12-16, release date: 2021-03-17, Last modification date: 2024-04-03)
Primary citation	Yu, E.C.,Methot, J.L.,Fradera, X.,Lesburg, C.A.,Lacey, B.M.,Siliphaivanh, P.,Liu, P.,Smith, D.M.,Xu, Z.,Piesvaux, J.A.,Kawamura, S.,Xu, H.,Miller, J.R.,Bittinger, M.,Pasternak, A. Identification of Potent Reverse Indazole Inhibitors for HPK1. Acs Med.Chem.Lett., 12:459-466, 2021 Cited by PubMed: 33738073 DOI: 10.1021/acsmedchemlett.0c00672 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation