7KXW

Crystal structure of DCLK1-KD in complex with DCLK1-IN-1

Summary for 7KXW

• Entry DOI: 10.2210/pdb7kxw/pdb
• Descriptor: Serine/threonine-protein kinase DCLK1, 2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-11-methyl-5-(2,2,2-trifluoroethyl)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• Functional Keywords: kinase, doublecortin-like, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 64034.90

Authors

Patel, O.,Lucet, I. (deposition date: 2020-12-05, release date: 2021-09-22, Last modification date: 2023-10-18)

• Primary citation: Patel, O.,Roy, M.J.,Kropp, A.,Hardy, J.M.,Dai, W.,Lucet, I.S.; Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1.; Commun Biol, 4:1105-1105, 2021; PubMed: 34545159; DOI: 10.1038/s42003-021-02631-y

Experimental method

X-RAY DIFFRACTION (3.002 Å)