7KP6

Structure of Ack1 kinase in complex with a selective inhibitor

Summary for 7KP6

• Entry DOI: 10.2210/pdb7kp6/pdb
• Descriptor: Activated CDC42 kinase 1, 5-chloro-N~2~-[4-(4-methylpiperazin-1-yl)phenyl]-N~4~-{[(2R)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: protein-inhibitor complex, tyrosine kinase, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 65867.64

Authors

Thakur, M.K.,Miller, W.T.,Mahajan, N.,Seeliger, M.A. (deposition date: 2020-11-10, release date: 2022-02-09, Last modification date: 2023-10-25)

• Primary citation: Sridaran, D.,Chouhan, S.,Mahajan, K.,Renganathan, A.,Weimholt, C.,Bhagwat, S.,Reimers, M.,Kim, E.H.,Thakur, M.K.,Saeed, M.A.,Pachynski, R.K.,Seeliger, M.A.,Miller, W.T.,Feng, F.Y.,Mahajan, N.P.; Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance.; Nat Commun, 13:6929-6929, 2022; PubMed: 36376335; DOI: 10.1038/s41467-022-34724-5

Experimental method

X-RAY DIFFRACTION (1.79 Å)