7KNW
Crystal structure of SND1 in complex with C-26-A2
Summary for 7KNW
Entry DOI | 10.2210/pdb7knw/pdb |
Descriptor | Staphylococcal nuclease domain-containing protein 1, GLYCEROL, 5-chloro-2-methoxy-N-([1,2,4]triazolo[1,5-a]pyridin-8-yl)benzene-1-sulfonamide, ... (4 entities in total) |
Functional Keywords | inhibitor, endonuclease, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 148819.34 |
Authors | Kang, Y. (deposition date: 2020-11-06, release date: 2021-12-08, Last modification date: 2022-02-16) |
Primary citation | Shen, M.,Wei, Y.,Kim, H.,Wan, L.,Jiang, Y.Z.,Hang, X.,Raba, M.,Remiszewski, S.,Rowicki, M.,Wu, C.G.,Wu, S.,Zhang, L.,Lu, X.,Yuan, M.,Smith, H.A.,Zheng, A.,Bertino, J.,Jin, J.F.,Xing, Y.,Shao, Z.M.,Kang, Y. Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat Cancer, 3:43-59, 2022 Cited by PubMed: 35121987DOI: 10.1038/s43018-021-00279-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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