7KL6

Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase

Summary for 7KL6

Entry DOI	10.2210/pdb7kl6/pdb
Descriptor	Phosphoribosyltransferase, (3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}propyl)phosphonic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	helicobacter pylori xanthine-guanine-hypoxanthine phosphoribosyltransferase drug discovery nucleoside phosphonates, transferase
Biological source	Helicobacter pylori
Total number of polymer chains	2
Total formula weight	37598.78
Authors	Guddat, L.W.,Keough, D.T. (deposition date: 2020-10-29, release date: 2021-05-05, Last modification date: 2024-03-06)
Primary citation	Keough, D.T.,Wun, S.J.,Baszczynski, O.,Eng, W.S.,Spacek, P.,Panjikar, S.,Naesens, L.,Pohl, R.,Rejman, D.,Hockova, D.,Ferrero, R.L.,Guddat, L.W. Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections. J.Med.Chem., 64:5710-5729, 2021 Cited by PubMed: 33891818 DOI: 10.1021/acs.jmedchem.0c02184 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation