7KKH

P1A4 Fab in complex with ARS1620

Summary for 7KKH

Entry DOI	10.2210/pdb7kkh/pdb
Descriptor	P1A4 Fab Light Chain, P1A4 Fab Heavy Chain, SODIUM ION, ... (5 entities in total)
Functional Keywords	fab, antibody, antitumor protein, immune system
Biological source	Homo sapiens More
Total number of polymer chains	2
Total formula weight	46682.18
Authors	Basu, K.,Rohweder, P.J.,Zhang, Z.,Bohn, M.-F.,Shokat, K.,Craik, C.S. (deposition date: 2020-10-27, release date: 2022-04-27, Last modification date: 2023-10-18)
Primary citation	Zhang, Z.,Rohweder, P.J.,Ongpipattanakul, C.,Basu, K.,Bohn, M.F.,Dugan, E.J.,Steri, V.,Hann, B.,Shokat, K.M.,Craik, C.S. A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy. Cancer Cell, 40:1060-1069.e7, 2022 Cited by PubMed: 36099883 DOI: 10.1016/j.ccell.2022.07.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation