7KGY

Beta-glucuronidase from Faecalibacterium prausnitzii bound to the inhibitor UNC10201652-glucuronide

Summary for 7KGY

• Entry DOI: 10.2210/pdb7kgy/pdb
• Descriptor: Beta-glucuronidase, 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, GLYCEROL, ... (4 entities in total)
• Functional Keywords: beta-glucuronidase, carbohydrate, glucuronic acid, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Faecalibacterium prausnitzii
• Total number of polymer chains: 4
• Total formula weight: 279049.28

Authors

Simpson, J.B.,Redinbo, M.R. (deposition date: 2020-10-19, release date: 2021-11-10, Last modification date: 2023-10-18)

• Primary citation: Zhang, J.,Walker, M.E.,Sanidad, K.Z.,Zhang, H.,Liang, Y.,Zhao, E.,Chacon-Vargas, K.,Yeliseyev, V.,Parsonnet, J.,Haggerty, T.D.,Wang, G.,Simpson, J.B.,Jariwala, P.B.,Beaty, V.V.,Yang, J.,Yang, H.,Panigrahy, A.,Minter, L.M.,Kim, D.,Gibbons, J.G.,Liu, L.,Li, Z.,Xiao, H.,Borlandelli, V.,Overkleeft, H.S.,Cloer, E.W.,Major, M.B.,Goldfarb, D.,Cai, Z.,Redinbo, M.R.,Zhang, G.; Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.; Nat Commun, 13:136-136, 2022; PubMed: 35013263; DOI: 10.1038/s41467-021-27762-y

Experimental method

X-RAY DIFFRACTION (2.2 Å)