7KA1
1.60 Angstrom resolution crystal structure of the beta-Q114A mutant Tryptophan Synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the alpha-site, aminoacrylate at the beta site, and cesium ion at the metal coordination site
Summary for 7KA1
Entry DOI | 10.2210/pdb7ka1/pdb |
Related | 4HN4 4HPX 6D0V 6X0C |
Descriptor | Tryptophan synthase alpha chain, DI(HYDROXYETHYL)ETHER, Tryptophan synthase beta chain, ... (11 entities in total) |
Functional Keywords | lyase, inhibitor, tryptophan synthase, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) More |
Total number of polymer chains | 2 |
Total formula weight | 74749.13 |
Authors | Hilario, E.,Dunn, M.F.,Mueller, L.J. (deposition date: 2020-09-29, release date: 2021-09-29, Last modification date: 2023-10-18) |
Primary citation | Hilario, E.,Dunn, M.F.,Mueller, L.J. 1.60 Angstrom resolution crystal structure of the beta-Q114A mutant Tryptophan Synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the alpha-site, aminoacrylate at the beta site, and cesium ion at the metal coordination site. To be Published, |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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