7K7Q
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-N-methylpyridazine-3-carboxamide
Summary for 7K7Q
Entry DOI | 10.2210/pdb7k7q/pdb |
Descriptor | Non-receptor tyrosine-protein kinase TYK2, 6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-N-methylpyridazine-3-carboxamide (3 entities in total) |
Functional Keywords | kinase, tyk2, pseudokinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 71979.34 |
Authors | Khan, J.A. (deposition date: 2020-09-23, release date: 2021-08-04, Last modification date: 2023-10-18) |
Primary citation | Liu, C.,Lin, J.,Langevine, C.,Smith, D.,Li, J.,Tokarski, J.S.,Khan, J.,Ruzanov, M.,Strnad, J.,Zupa-Fernandez, A.,Cheng, L.,Gillooly, K.M.,Shuster, D.,Zhang, Y.,Thankappan, A.,McIntyre, K.W.,Chaudhry, C.,Elzinga, P.A.,Chiney, M.,Chimalakonda, A.,Lombardo, L.J.,Macor, J.E.,Carter, P.H.,Burke, J.R.,Weinstein, D.S. Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2. J.Med.Chem., 64:677-694, 2021 Cited by PubMed: 33370104DOI: 10.1021/acs.jmedchem.0c01698 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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