7K66

Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor

Summary for 7K66

• Entry DOI: 10.2210/pdb7k66/pdb
• Related: 6MF0
• Descriptor: Coagulation factor VIII,Coagulation factor VIII,Coagulation factor VIII,Coagulation factor VIII, 2A9 heavy chain, 2A9 light chain, ... (10 entities in total)
• Functional Keywords: antibody, inhibitor, blood clotting, blood clotting-immune system complex, blood clotting/immune system
• Biological source: Sus scrofa (Pig); More
• Total number of polymer chains: 3
• Total formula weight: 217290.01

Authors

Childers, K.C.,Gish, J.,Jarvis, L.,Peters, S.,Garrels, C.,Smith, I.W.,Spencer, H.T.,Spiegel, P.C. (deposition date: 2020-09-18, release date: 2020-10-14, Last modification date: 2023-10-18)

• Primary citation: Gish, J.S.,Jarvis, L.,Childers, K.C.,Peters, S.C.,Garrels, C.S.,Smith, I.W.,Spencer, H.T.,Doering, C.B.,Lollar, P.,Spiegel, P.C.; Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor.; Blood, 137:2981-2986, 2021; PubMed: 33529335; DOI: 10.1182/blood.2020008940

Experimental method

X-RAY DIFFRACTION (3.92 Å)