7JWL

Crystal Structure of Pseudomonas aeruginosa Penicillin Binding Protein 3 (PAE-PBP3) bound to ETX0462

Summary for 7JWL

• Entry DOI: 10.2210/pdb7jwl/pdb
• Descriptor: Peptidoglycan D,D-transpeptidase FtsI, CHLORIDE ION, ETX0462 (Bound form), ... (4 entities in total)
• Functional Keywords: pseudomonas aeruginosa, pbp3, etx0462, antibiotic
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 58729.24

Authors

Mayclin, S.J.,Abendroth, J.,Horanyi, P.S.,Sylvester, M.,Wu, X.,Shapiro, A.,Moussa, S.,Durand-Reville, T.F. (deposition date: 2020-08-25, release date: 2021-05-26, Last modification date: 2023-10-18)

• Primary citation: Durand-Reville, T.F.,Miller, A.A.,O'Donnell, J.P.,Wu, X.,Sylvester, M.A.,Guler, S.,Iyer, R.,Shapiro, A.B.,Carter, N.M.,Velez-Vega, C.,Moussa, S.H.,McLeod, S.M.,Chen, A.,Tanudra, A.M.,Zhang, J.,Comita-Prevoir, J.,Romero, J.A.,Huynh, H.,Ferguson, A.D.,Horanyi, P.S.,Mayclin, S.J.,Heine, H.S.,Drusano, G.L.,Cummings, J.E.,Slayden, R.A.,Tommasi, R.A.; Rational design of a new antibiotic class for drug-resistant infections.; Nature, 597:698-702, 2021; PubMed: 34526714; DOI: 10.1038/s41586-021-03899-0

Experimental method

X-RAY DIFFRACTION (2.2 Å)