7JK7
Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant
Summary for 7JK7
Entry DOI | 10.2210/pdb7jk7/pdb |
Descriptor | Lysine-specific histone demethylase 1A, Importin subunit alpha-1, GLYCEROL, ... (4 entities in total) |
Functional Keywords | importin alpha demethylase nuclear localisation, protein transport |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 54525.69 |
Authors | Tu, W.J.,McCuaig, R.,Tan, A.H.Y.,Hardy, K.,Seddiki, N.,Ali, S.,Dahlstron, J.E.,Bean, E.G.,Dunn, J.,Forwood, J.K.,Tsimbalyuk, S.,Smith, K.M.,Yip, D.,Malik, L.,Prasana, T.,Milburn, P.,Rao, S. (deposition date: 2020-07-27, release date: 2020-08-05, Last modification date: 2023-10-18) |
Primary citation | Tu, W.J.,McCuaig, R.D.,Tan, A.H.Y.,Hardy, K.,Seddiki, N.,Ali, S.,Dahlstrom, J.E.,Bean, E.G.,Dunn, J.,Forwood, J.,Tsimbalyuk, S.,Smith, K.,Yip, D.,Malik, L.,Prasanna, T.,Milburn, P.,Rao, S. Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch. Front Immunol, 11:1228-, 2020 Cited by DOI: 10.3389/fimmu.2020.01228PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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