7JGW

Crystal structure of BCL-XL in complex with COMPOUND 1620116, CRYSTAL FORM 1

Summary for 7JGW

• Entry DOI: 10.2210/pdb7jgw/pdb
• Descriptor: Bcl-2-like protein 1, 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid (3 entities in total)
• Functional Keywords: apoptosis, alternative splicing, membrane, mitochondrion
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 18535.68

Authors

Lee, M.,Fairlie, W.D.,Smith, B.J.,Lee, E.F. (deposition date: 2020-07-19, release date: 2021-02-24, Last modification date: 2023-10-18)

• Primary citation: Nguyen, W.,Lee, E.F.,Evangelista, M.,Lee, M.,Harris, T.J.,Colman, P.M.,Smith, N.A.,Williams, L.B.,Jarman, K.E.,Lowes, K.N.,Haeberli, C.,Keiser, J.,Smith, B.J.,Fairlie, W.D.,Sleebs, B.E.; Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.; Acs Infect Dis., 7:1143-1163, 2021; PubMed: 33523649; DOI: 10.1021/acsinfecdis.0c00700

Experimental method

X-RAY DIFFRACTION (1.3 Å)