7JG4

Human GAR transformylase in complex with GAR substrate and AGF131 inhibitor

Summary for 7JG4

• Entry DOI: 10.2210/pdb7jg4/pdb
• Related: 7JG0 7JG3
• Descriptor: Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-(5-{3-[(1S,7R,8R,9S)-4-amino-2-oxo-7lambda~4~-thia-3,5-diazatetracyclo[4.3.0.0~1,7~.0~7,9~]nona-3,5-dien-8-yl]propyl}thiophene-2-carbonyl)-L-glutamic acid, ... (5 entities in total)
• Functional Keywords: garftase, formyltransferase, transformylase, enzyme protein inhibitor, metabolism, alpha beta protein, rossman fold, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 23581.80

Authors

Wong-Roushar, J.,Dann III, C.E. (deposition date: 2020-07-18, release date: 2021-03-31, Last modification date: 2023-10-18)

• Primary citation: Wallace-Povirk, A.,Tong, N.,Wong-Roushar, J.,O'Connor, C.,Zhou, X.,Hou, Z.,Bao, X.,Garcia, G.E.,Li, J.,Kim, S.,Dann III, C.E.,Matherly, L.H.,Gangjee, A.; Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors; Bioorg.Med.Chem., 37:116093-, 2021; DOI: 10.1016/j.bmc.2021.116093

Experimental method

X-RAY DIFFRACTION (2.455 Å)