7FVS
Crystal Structure of S. aureus gyrase in complex with 4-[[1-[(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridin-6-yl)methyl]azetidin-3-yl]methylamino]-6-fluorochromen-2-one
Summary for 7FVS
| Entry DOI | 10.2210/pdb7fvs/pdb |
| Group deposition | A set of S. aureus gyrase BA fusion crystal structures (G_1002266) |
| Descriptor | DNA gyrase subunit B,DNA gyrase subunit A Chimera, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), MANGANESE (II) ION, ... (7 entities in total) |
| Functional Keywords | dna gyrase, topoisomerase;, isomerase |
| Biological source | Staphylococcus aureus subsp. aureus N315 More |
| Total number of polymer chains | 4 |
| Total formula weight | 169163.09 |
| Authors | Xu, B.,Benz, J.,Cumming, J.G.,Kreis, L.,Rudolph, M.G. (deposition date: 2023-04-18, release date: 2023-06-28, Last modification date: 2023-08-16) |
| Primary citation | Cumming, J.G.,Kreis, L.,Kuhne, H.,Wermuth, R.,Vercruysse, M.,Kramer, C.,Rudolph, M.G.,Xu, Z. Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens. Acs Med.Chem.Lett., 14:993-998, 2023 Cited by PubMed: 37465290DOI: 10.1021/acsmedchemlett.3c00187 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.16 Å) |
Structure validation
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