7FQH

Crystal Structure of human Legumain in complex with (2S)-N-[(3S)-5-amino-5-oxopent-1-yn-3-yl]-1-[1-[4-(cyclopropylmethoxy)phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide

Summary for 7FQH

• Entry DOI: 10.2210/pdb7fqh/pdb
• Group deposition: To be published (G_1002245)
• Descriptor: Legumain, N-[(3S)-5-amino-5-oxopent-1-en-3-yl]-1-{1-[4-(cyclopropylmethoxy)phenyl]cyclopropane-1-carbonyl}-L-prolinamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: cysteine protease, allosteric inhibitor, asparaginyl endopeptidase, alzheimer's disease, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 154476.13

Authors

Ehler, A.,Benz, J.,Bartels, B.,Hewings-David, S.,Rudolph, M.G. (deposition date: 2022-10-05, release date: 2023-10-11, Last modification date: 2023-11-15)

• Primary citation: Bartels, B.,Kuhn, B.,Benz, J.,Rudolph, M.G.; Crystal Structure of a human Legumain complex; To be published,

Experimental method

X-RAY DIFFRACTION (2.18 Å)