7FCZ

Crystal Structure of human RIPK1 kinase domain in complex with a novel inhibitor

Summary for 7FCZ

• Entry DOI: 10.2210/pdb7fcz/pdb
• Descriptor: Receptor-interacting serine/threonine-protein kinase 1, N-[(3S)-7-(2-cyclopropylethynyl)-5-methyl-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4H-1,2,4-triazole-3-carboxamide (3 entities in total)
• Functional Keywords: immune system-inhibitor complex, immune system/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 68250.82

Authors

Su, H.X.,Xie, H.,Nie, T.Q.,Li, M.J.,Xu, Y.C. (deposition date: 2021-07-15, release date: 2022-01-19, Last modification date: 2023-11-29)

• Primary citation: Yang, X.,Lu, H.,Xie, H.,Zhang, B.,Nie, T.,Fan, C.,Yang, T.,Xu, Y.,Su, H.,Tang, W.,Zhou, B.; Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis.; Angew.Chem.Int.Ed.Engl., 61:e202114922-e202114922, 2022; PubMed: 34851543; DOI: 10.1002/anie.202114922

Experimental method

X-RAY DIFFRACTION (2.21 Å)