7FAL

Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with T36 and L-pro

Summary for 7FAL

• Entry DOI: 10.2210/pdb7fal/pdb
• Descriptor: Prolyl-tRNA synthetase (ProRS), 4-[(3R)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, ... (4 entities in total)
• Functional Keywords: inhibitor-bound structural comparison, translation, multi-drug, translation-inhibitor complex, translation/inhibitor
• Biological source: Toxoplasma gondii
• Total number of polymer chains: 2
• Total formula weight: 117077.86

Authors

Malhotra, N.,Mishra, S.,Yogavel, M.,Sharma, A. (deposition date: 2021-07-06, release date: 2022-08-31, Last modification date: 2023-11-29)

• Primary citation: Yogavel, M.,Bougdour, A.,Mishra, S.,Malhotra, N.,Chhibber-Goel, J.,Bellini, V.,Harlos, K.,Laleu, B.,Hakimi, M.A.,Sharma, A.; Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.; Plos Pathog., 19:e1011124-e1011124, 2023; PubMed: 36854028; DOI: 10.1371/journal.ppat.1011124

Experimental method

X-RAY DIFFRACTION (3.219 Å)