7F35

Crystal structure of anti S-gatifloxacin antibody Fab fragment in complex with S-gatifloxacin

Summary for 7F35

• Entry DOI: 10.2210/pdb7f35/pdb
• Related: 7F2S
• Descriptor: Antibody Fab fragment light chain, Antibody Fab fragment heavy chain, 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, ... (10 entities in total)
• Functional Keywords: antibody, gatifloxacin, fab fragment, enantioselectivity, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 6
• Total formula weight: 145696.50

Authors

Wang, L.T.,Jiao, W.Y.,Shen, X.,Lei, H.T. (deposition date: 2021-06-15, release date: 2021-12-29, Last modification date: 2023-11-29)

• Primary citation: Wang, L.T.,Xie, W.,Jiao, W.Y.,Zhang, C.,Li, X.,Xu, Z.,Huang, X.,Lei, H.T.,Shen, X.; Conformational adaptability determining antibody recognition to distomer: structure analysis of enantioselective antibody against chiral drug gatifloxacin; Rsc Adv, 11:39534-39544, 2021; DOI: 10.1039/D1RA07143B

Experimental method

X-RAY DIFFRACTION (2.6 Å)