7EPW

Crystal structure of monooxygenase Tet(X4) with tigecycline

Summary for 7EPW

• Entry DOI: 10.2210/pdb7epw/pdb
• Descriptor: Flavin-dependent monooxygenase, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, TIGECYCLINE, ... (4 entities in total)
• Functional Keywords: monooxygenase, tet(x4), tigecycline resistance, oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 44719.20

Authors

Cheng, Q.,Chen, S. (deposition date: 2021-04-28, release date: 2021-11-10, Last modification date: 2023-11-29)

• Primary citation: Cheng, Q.,Cheung, Y.,Liu, C.,Xiao, Q.,Sun, B.,Zhou, J.,Chan, E.W.C.,Zhang, R.,Chen, S.; Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline.; Bmc Biol., 19:262-262, 2021; PubMed: 34895224; DOI: 10.1186/s12915-021-01199-7

Experimental method

X-RAY DIFFRACTION (2.23 Å)