7EPB

Cryo-EM structure of LY354740-bound mGlu2 homodimer

Summary for 7EPB

• Entry DOI: 10.2210/pdb7epb/pdb
• EMDB information: 31236
• Descriptor: Metabotropic glutamate receptor 2, Anti-RON nanobody, (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (3 entities in total)
• Functional Keywords: cryo-em structure, membrane protein, gpcr
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 218908.98

Authors

Du, J.,Wang, D.,Fan, H.,Tai, L.,Lin, S.,Han, S.,Sun, F.,Wu, B.,Zhao, Q. (deposition date: 2021-04-26, release date: 2021-06-23, Last modification date: 2021-07-07)

• Primary citation: Du, J.,Wang, D.,Fan, H.,Xu, C.,Tai, L.,Lin, S.,Han, S.,Tan, Q.,Wang, X.,Xu, T.,Zhang, H.,Chu, X.,Yi, C.,Liu, P.,Wang, X.,Zhou, Y.,Pin, J.P.,Rondard, P.,Liu, H.,Liu, J.,Sun, F.,Wu, B.,Zhao, Q.; Structures of human mGlu2 and mGlu7 homo- and heterodimers.; Nature, 594:589-593, 2021; PubMed: 34135509; DOI: 10.1038/s41586-021-03641-w

Experimental method

ELECTRON MICROSCOPY (3.1 Å)