7ELB

Structure of Machupo virus L polymerase in complex with Z protein (dimeric form)

Summary for 7ELB

• Entry DOI: 10.2210/pdb7elb/pdb
• EMDB information: 31179
• Descriptor: RNA-directed RNA polymerase L, RING finger protein Z, MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: rna virus, polymerase, replication, transcription, matrix protein, viral protein
• Biological source: Machupo mammarenavirus (MACV); More
• Total number of polymer chains: 4
• Total formula weight: 522785.80

Authors

Peng, R.,Xu, X.,Peng, Q.,Shi, Y. (deposition date: 2021-04-09, release date: 2021-05-05, Last modification date: 2021-07-14)

• Primary citation: Xu, X.,Peng, R.,Peng, Q.,Wang, M.,Xu, Y.,Liu, S.,Tian, X.,Deng, H.,Tong, Y.,Hu, X.,Zhong, J.,Wang, P.,Qi, J.,Gao, G.F.,Shi, Y.; Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.; Nat Microbiol, 6:921-931, 2021; PubMed: 34127846; DOI: 10.1038/s41564-021-00916-w

Experimental method

ELECTRON MICROSCOPY (4.1 Å)