7E72

Crystal structure of Tie2-agonistic antibody in complex with human Tie2 Fn2-3

Summary for 7E72

Entry DOI	10.2210/pdb7e72/pdb
Descriptor	the chimeric Fab fragment of 3H7 (heavy chain), the chimeric Fab fragment of 3H7 (light chain), Angiopoietin-1 receptor, ... (5 entities in total)
Functional Keywords	antigen-antibody complex, agonistic antibody, angiogenesis, vascular stabilization, receptor tyrosine kinase, tie2, membrane protein
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	142430.71
Authors	Kim, H.M.,Jo, G.H.,Hong, H.J.,Han, A. (deposition date: 2021-02-25, release date: 2021-11-10, Last modification date: 2023-11-29)
Primary citation	Jo, G.,Bae, J.,Hong, H.J.,Han, A.R.,Kim, D.K.,Hong, S.P.,Kim, J.A.,Lee, S.,Koh, G.Y.,Kim, H.M. Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody. Nat Commun, 12:6287-6287, 2021 Cited by PubMed: 34725372 DOI: 10.1038/s41467-021-26620-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.094 Å)

Structure validation