7E4Y
Crystal structure of tubulin in complex with L-DM4-SMe
Summary for 7E4Y
| Entry DOI | 10.2210/pdb7e4y/pdb |
| Descriptor | Tubulin alpha-1B chain, (1S,2S,3S,5R,6S,16E,18E,20S,21R)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-methyl-3-(methyldisulfanyl)butanoyl]amino}propanoate (non-preferred name), PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
| Functional Keywords | microtubule assembly inhibitors, structural protein-inhibitor complex, structural protein/inhibitor |
| Biological source | Bos taurus (Bovine) More |
| Total number of polymer chains | 6 |
| Total formula weight | 258551.21 |
| Authors | |
| Primary citation | Wang, Y.,Li, W. C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids To Be Published, |
| Experimental method | X-RAY DIFFRACTION (2.708 Å) |
Structure validation
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