7DW6

SARS-CoV-2 Mpro mutant (H41A) in complex with nsp15|16 peptidyl substrate

Summary for 7DW6

• Entry DOI: 10.2210/pdb7dw6/pdb
• Descriptor: 3C-like proteinase, nsp15/16 peptidyl substrate (3 entities in total)
• Functional Keywords: protease, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 2
• Total formula weight: 36033.99

Authors

Liu, X.,Zhao, Y.,Yang, H.,Rao, Z. (deposition date: 2021-01-15, release date: 2022-01-19, Last modification date: 2023-11-29)

• Primary citation: Zhao, Y.,Zhu, Y.,Liu, X.,Jin, Z.,Duan, Y.,Zhang, Q.,Wu, C.,Feng, L.,Du, X.,Zhao, J.,Shao, M.,Zhang, B.,Yang, X.,Wu, L.,Ji, X.,Guddat, L.W.,Yang, K.,Rao, Z.,Yang, H.; Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.; Proc.Natl.Acad.Sci.USA, 119:e2117142119-e2117142119, 2022; PubMed: 35380892; DOI: 10.1073/pnas.2117142119

Experimental method

X-RAY DIFFRACTION (1.7 Å)