Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7DPI

Plasmodium falciparum cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD7929

Summary for 7DPI
Entry DOI10.2210/pdb7dpi/pdb
DescriptorPhenylalanine--tRNA ligase, Phenylalanyl-tRNA synthetase beta subunit, (8R,9S,10S)-10-[(dimethylamino)methyl]-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, ... (4 entities in total)
Functional Keywordsaminoacylation, aminoacyl-trna synthetase, trna-binding, atp-binding, auxiliary pocket, heterotetrameric, ligase
Biological sourcePlasmodium falciparum
More
Total number of polymer chains4
Total formula weight219180.68
Authors
Manmohan, S.,Malhotra, N.,Harlos, K.,Manickam, Y.,Sharma, A. (deposition date: 2020-12-19, release date: 2022-03-23, Last modification date: 2024-05-29)
Primary citationSharma, M.,Mutharasappan, N.,Manickam, Y.,Harlos, K.,Melillo, B.,Comer, E.,Tabassum, H.,Parvez, S.,Schreiber, S.L.,Sharma, A.
Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development.
Structure, 30:962-972.e3, 2022
Cited by
PubMed: 35460612
DOI: 10.1016/j.str.2022.03.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.597 Å)
Structure validation

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon