7DMY

The crystal structure of Cpd7 in complex with BPTF bromodomain

Summary for 7DMY

• Entry DOI: 10.2210/pdb7dmy/pdb
• Descriptor: Nucleosome-remodeling factor subunit BPTF, tert-butyl 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-4-oxidanylidene-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylate (3 entities in total)
• Functional Keywords: inhibitor;bptf;bromodomain, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 17366.64

Authors

Xiong, L.,Guo, Y.,Yang, S. (deposition date: 2020-12-08, release date: 2021-10-20, Last modification date: 2023-11-29)

• Primary citation: Xiong, L.,Mao, X.,Guo, Y.,Zhou, Y.,Chen, M.,Chen, P.,Yang, S.,Li, L.; Discovery of selective BPTF bromodomain inhibitors by screening and structure-based optimization.; Biochem.Biophys.Res.Commun., 545:125-131, 2021; PubMed: 33548625; DOI: 10.1016/j.bbrc.2021.01.067

Experimental method

X-RAY DIFFRACTION (2 Å)