7DI7

Falcilysin in complex with chloroquine

Summary for 7DI7

Entry DOI	10.2210/pdb7di7/pdb
Descriptor	Falcilysin, ACETATE ION, N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE, ... (5 entities in total)
Functional Keywords	protein binding-inhibitor complex, protein binding/inhibitor
Biological source	Plasmodium falciparum 3D7
Total number of polymer chains	1
Total formula weight	135542.73
Authors	Lin, J.Q.,El Sahili, A.,Lescar, J. (deposition date: 2020-11-18, release date: 2021-12-01, Last modification date: 2024-05-29)
Primary citation	Wirjanata, G.,Lin, J.,Dziekan, J.M.,El Sahili, A.,Chung, Z.,Tjia, S.,Binte Zulkifli, N.E.,Boentoro, J.,Tham, R.,Jia, L.S.,Go, K.D.,Yu, H.,Partridge, A.,Olsen, D.,Prabhu, N.,Sobota, R.M.,Nordlund, P.,Lescar, J.,Bozdech, Z. Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development. Cell Chem Biol, 31:743-759.e8, 2024 Cited by PubMed: 38593807 DOI: 10.1016/j.chembiol.2024.03.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation