7DCF

Crystal structure of EHMT2 SET domain in complex with compound 10

Summary for 7DCF

• Entry DOI: 10.2210/pdb7dcf/pdb
• Descriptor: Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
• Functional Keywords: protein-small molecule inhibitor complex, transferase-transferase inhibitor complex, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 67152.84

Authors

Suzuki, M.,Katayama, K. (deposition date: 2020-10-26, release date: 2021-02-10, Last modification date: 2024-03-27)

• Primary citation: Katayama, K.,Ishii, K.,Terashima, H.,Tsuda, E.,Suzuki, M.,Yotsumoto, K.,Hiramoto, K.,Yasumatsu, I.,Torihata, M.,Ishiyama, T.,Muto, T.,Katagiri, T.; Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating beta-Thalassemia and Sickle Cell Disease.; Acs Med.Chem.Lett., 12:121-128, 2021; PubMed: 33488973; DOI: 10.1021/acsmedchemlett.0c00572

Experimental method

X-RAY DIFFRACTION (1.8 Å)