7DAE

EPB in complex with tubulin

Summary for 7DAE

• Entry DOI: 10.2210/pdb7dae/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE, ... (13 entities in total)
• Functional Keywords: phomopsin a, tubulin, protein-drug complex, cell cycle
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 6
• Total formula weight: 265260.43

Authors

Wu, C.,Wang, Y. (deposition date: 2020-10-16, release date: 2021-03-24, Last modification date: 2023-11-29)

• Primary citation: Xiao, Q.,Xue, T.,Shuai, W.,Wu, C.,Zhang, Z.,Zhang, T.,Zeng, S.,Sun, B.,Wang, Y.; High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design.; Biochem.Biophys.Res.Commun., 534:330-336, 2021; PubMed: 33272565; DOI: 10.1016/j.bbrc.2020.11.082

Experimental method

X-RAY DIFFRACTION (2.394 Å)