7D4B

Crystal structure of 4-1BB in complex with a VHH

Summary for 7D4B

• Entry DOI: 10.2210/pdb7d4b/pdb
• Descriptor: Tumor necrosis factor receptor superfamily member 9, anti-4-1BB VHH, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: antibody, complex, vhh, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 31206.71

Authors

Wang, C. (deposition date: 2020-09-23, release date: 2021-07-14, Last modification date: 2023-11-29)

• Primary citation: Zhai, T.,Wang, C.,Xu, Y.,Huang, W.,Yuan, Z.,Wang, T.,Dai, S.,Peng, S.,Pang, T.,Jiang, W.,Huang, Y.,Zou, Y.,Xu, Y.,Sun, J.,Gong, X.,Zhang, J.,Tsun, A.,Li, B.,Miao, X.; Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer.; J Immunother Cancer, 9:-, 2021; PubMed: 34172514; DOI: 10.1136/jitc-2020-002131

Experimental method

X-RAY DIFFRACTION (3.14 Å)