7D21

Crystal structure of Ixodes scapularis glutaminyl cyclase with two Zn ions bound to the active site

Summary for 7D21

• Entry DOI: 10.2210/pdb7d21/pdb
• Descriptor: Glutaminyl-peptide cyclotransferase, ZINC ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: glutaminyl cyclase, metal binding protein, transferase
• Biological source: Ixodes scapularis (Black-legged tick)
• Total number of polymer chains: 1
• Total formula weight: 38813.46

Authors

Huang, K.-F.,Huang, J.-S.,Wu, M.-L.,Hsieh, W.-L.,Wang, A.H.-J. (deposition date: 2020-09-15, release date: 2021-04-14, Last modification date: 2023-11-29)

• Primary citation: Huang, K.F.,Huang, J.S.,Wu, M.L.,Hsieh, W.L.,Hsu, K.C.,Hsu, H.L.,Ko, T.P.,Wang, A.H.; A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes.; J.Mol.Biol., 433:166960-166960, 2021; PubMed: 33774034; DOI: 10.1016/j.jmb.2021.166960

Experimental method

X-RAY DIFFRACTION (1.97 Å)