7CU5

N-Glycosylation of PD-1 and glycosylation dependent binding of PD-1 specific monoclonal antibody camrelizumab

Summary for 7CU5

Entry DOI	10.2210/pdb7cu5/pdb
Descriptor	camrelizumab-scFv, Programmed cell death protein 1, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	camrelizumab, glycosylation, pd-1., immune system
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	79833.54
Authors	Liu, K.F.,Tan, S.G.,Jin, W.J.,Guan, J.W.,Wang, W.L.,Sun, H.,Qi, J.X.,Yan, J.H.,Chai, Y.,Wang, Z.F.,Chu, X.D.,Gao, G.F. (deposition date: 2020-08-21, release date: 2020-10-14, Last modification date: 2023-11-29)
Primary citation	Liu, K.,Tan, S.,Jin, W.,Guan, J.,Wang, Q.,Sun, H.,Qi, J.,Yan, J.,Chai, Y.,Wang, Z.,Deng, C.,Gao, G.F. N-glycosylation of PD-1 promotes binding of camrelizumab. Embo Rep., 21:e51444-e51444, 2020 Cited by PubMed: 33063473 DOI: 10.15252/embr.202051444 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.81 Å)

Structure validation