7CLD

Crystal structure of T2R-TTL-Cevipabulin complex

Summary for 7CLD

Entry DOI	10.2210/pdb7cld/pdb
Descriptor	Tubulin alpha-1B chain, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywords	tubulin inhibitor, tublin, structural protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	6
Total formula weight	265349.88
Authors	Chen, L.J.,Chen, Q.,Yu, Y.,Yang, J.H. (deposition date: 2020-07-20, release date: 2021-07-07, Last modification date: 2023-11-29)
Primary citation	Yang, J.,Yu, Y.,Li, Y.,Yan, W.,Ye, H.,Niu, L.,Tang, M.,Wang, Z.,Yang, Z.,Pei, H.,Wei, H.,Zhao, M.,Wen, J.,Yang, L.,Ouyang, L.,Wei, Y.,Chen, Q.,Li, W.,Chen, L. Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect. Sci Adv, 7:-, 2021 Cited by PubMed: 34138737 DOI: 10.1126/sciadv.abg4168 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.611 Å)

Structure validation