7CIO

Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase

Summary for 7CIO

Entry DOI	10.2210/pdb7cio/pdb
Descriptor	Phosphatidylinositol 3-kinase regulatory subunit alpha, Cytotoxic T-lymphocyte protein 4 (3 entities in total)
Functional Keywords	t-cell, cd28, phosphopeptides, protein engineering, thermostability, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	13149.56
Authors	Iiyama, M.,Numoto, N.,Ogawa, S.,Kuroda, M.,Morii, H.,Abe, R.,Ito, N.,Oda, M. (deposition date: 2020-07-08, release date: 2020-12-09, Last modification date: 2023-11-29)
Primary citation	Iiyama, M.,Numoto, N.,Ogawa, S.,Kuroda, M.,Morii, H.,Abe, R.,Ito, N.,Oda, M. Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains. Mol.Immunol., 131:51-59, 2021 Cited by PubMed: 33386150 DOI: 10.1016/j.molimm.2020.12.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation