7C6P

Bromodomain-containing 4 BD2 in complex with 3',4',7,8- Tetrahydroxyflavonoid

Summary for 7C6P

Entry DOI	10.2210/pdb7c6p/pdb
Descriptor	Bromodomain-containing protein 4, 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one (3 entities in total)
Functional Keywords	brd4, bd2, 3', 4', 7, 8- tetrahydroxyflavonoid, acute myeloid leukemia, c-myc, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	13093.17
Authors	Li, J.,Yu, K.,Luo, Y.,Zheng, W.,Liang, W.,Zhu, J. (deposition date: 2020-05-22, release date: 2021-05-12, Last modification date: 2023-11-29)
Primary citation	Li, J.,Zou, W.,Yu, K.,Liu, B.,Liang, W.,Wang, L.,Lu, Y.,Jiang, Z.,Wang, A.,Zhu, J. Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem, 36:903-913, 2021 Cited by PubMed: 33820450 DOI: 10.1080/14756366.2021.1906663 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation