7C05
Crystal structure of human Trap1 with DN203495
Summary for 7C05
Entry DOI | 10.2210/pdb7c05/pdb |
Descriptor | Heat shock protein 75 kDa, mitochondrial, 1-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-4-chloranyl-pyrazolo[3,4-d]pyrimidin-6-amine (3 entities in total) |
Functional Keywords | trap1, selectivity, mitochondria, hsp90, anticancer, drug, chaperone |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 57778.67 |
Authors | |
Primary citation | Kim, D.,Kim, S.Y.,Kim, D.,Yoon, N.G.,Yun, J.,Hong, K.B.,Lee, C.,Lee, J.H.,Kang, B.H.,Kang, S. Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models. Bioorg.Chem., 101:103901-103901, 2020 Cited by PubMed: 32590225DOI: 10.1016/j.bioorg.2020.103901 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
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